23LX

Crystal structure of SARS-CoV-2 main protease P168 deletion mutant in complex with leritrelvir

Summary for 23LX

• Entry DOI: 10.2210/pdb23lx/pdb
• Related: 8ign
• Descriptor: 3C-like proteinase nsp5, Leritrelvir bound form (3 entities in total)
• Functional Keywords: sars-cov-2, nsp5, main protease, coronavirus, protease inhibitor, alpha-ketoamide inhibitor, peptidomimetic inhibitor, viral protein
• Biological source: Severe acute respiratory syndrome coronavirus 2
• Total number of polymer chains: 1
• Total formula weight: 34370.15

Authors

Huang, X.,Li, Q.,Yang, Z.,Zhong, N.,Xiong, X. (deposition date: 2026-02-11, release date: 2026-06-03)

• Primary citation: Huang, X.,Kuzmic, P.,Zhang, S.,Chen, X.,Gui, J.,Li, Q.,Zou, B.,Yan, S.,Song, L.,Niu, C.,Zhao, Y.,Lin, H.,Wang, N.,Chen, J.,Chen, X.,Chen, J.,Zhong, N.,Yang, Z.,Xiong, X.; Superior Target Binding by Leritrelvir Induces Dimerization of Mpro Mutants and Mitigates Drug Resistance; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.7 Å)