23FW

Crystal structure of human PKMYT1 protein kinase domain with Naphthyridinone Inhibitor compound 16

This is a non-PDB format compatible entry.

Summary for 23FW

• Entry DOI: 10.2210/pdb23fw/pdb
• Descriptor: Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase, 9-azanyl-10-(7-fluoranyl-1H-indazol-4-yl)-6-methyl-2,3,4,7-tetrahydropyrano[2,3-f][1,7]naphthyridin-8-one, DIMETHYL SULFOXIDE, ... (6 entities in total)
• Functional Keywords: structural genomics, structural genomics consortium, sgc, protein kinase, tyrosine- and threonine-specific kinase, membrane-associated protein kinase, transferase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 65796.16

Authors

Xu, Z.,Chen, S. (deposition date: 2026-02-05, release date: 2026-03-25)

• Primary citation: Xu, Z.H.,Chen, S.; Discovery of Naphthyridinone Derivatives as Selective PKMYT1/WEE1 Dual Inhibitors; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.59 Å)