22WT

local refinement of 5HT2BR-fab heterotrimer in complex with a novel antagonist IHCH-2330

This is a non-PDB format compatible entry.

Summary for 22WT

• Entry DOI: 10.2210/pdb22wt/pdb
• EMDB information: 68739
• Descriptor: 5-hydroxytryptamine receptor 2B, 2-acetamido-2-deoxy-beta-D-glucopyranose, 3-[2-[2-[2,5-dimethoxy-4-(trifluoromethyl)phenyl]ethyl-methyl-amino]ethyl]-2-methyl-pyrido[1,2-a]pyrimidin-4-one (3 entities in total)
• Functional Keywords: gpcr, serotonin receptor, membrane protein, 5ht2br
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 32189.35

Authors

Tang, L.,Ji, X.,Cheng, J.,Wang, S. (deposition date: 2026-01-26, release date: 2026-09-16)

• Primary citation: Tang, L.,Ji, X.,Wang, Y.,Cao, D.,Li, H.,He, L.,Cheng, J.,Wang, S.; Mechanistic Basis for 5-HT2AR Over 5-HT2BR Activation; To Be Published,

Experimental method

ELECTRON MICROSCOPY (3.21 Å)