22TA

5HT2AR-miniGq heterotrimer in complex with a novel agonist IHCH-8152

This is a non-PDB format compatible entry.

Summary for 22TA

• Entry DOI: 10.2210/pdb22ta/pdb
• EMDB information: 68650
• Descriptor: 5-hydroxytryptamine receptor 2A, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2,Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... (5 entities in total)
• Functional Keywords: gpcr, serotonin receptor, membrane protein, 5ht2ar
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 4
• Total formula weight: 139258.72

Authors

Tang, L.,Cao, M.,Li, H.,Meng, B.,Liu, Z.,Cheng, J.,Wang, S. (deposition date: 2026-01-22, release date: 2026-10-21)

• Primary citation: He, L.,Tang, L.,Cao, D.,Duan, W.,Yu, J.,Zhang, P.,Li, H.,Wang, Y.,Meng, B.,Wang, H.,Zhou, Y.,Li, W.,Li, X.,Liu, Z.,Zhang, L.,Li, L.,Cheng, J.,Wang, S.; Mechanisms Underlying Sustained Antidepressant Effects of Psychedelics Inspire Microdosing Strategies; To Be Published,

Experimental method

ELECTRON MICROSCOPY (3.2 Å)