22JY
P301L/S320F human tau filaments from mouse brain
Summary for 22JY
| Entry DOI | 10.2210/pdb22jy/pdb |
| EMDB information | 68389 |
| Descriptor | Microtubule-associated protein tau (1 entity in total) |
| Functional Keywords | amyloid fibril, alzheimer disease, pick disease tau, tauopathy, protein fibril |
| Biological source | Homo sapiens (human) |
| Total number of polymer chains | 5 |
| Total formula weight | 27326.77 |
| Authors | Yanagisawa, H.,Kano, M.,Kimura, T.,Kikkawa, M.,Tomita, T. (deposition date: 2026-01-14, release date: 2026-02-04) |
| Primary citation | Kano, M.,Kimura, T.,Yanagisawa, H.,Tatsumi, L.,Yamashita, K.,Sakai, A.,Li, X.,Saido, T.C.,Saito, T.,Takatori, S.,Kikkawa, M.,Tomita, T. Cryo-EM structure of pro-aggregant P301L/S320F double-mutant tau filaments formed in mouse brains following peripheral AAV delivery Biorxiv, 2026 Cited by DOI: 10.64898/2026.01.19.700132PDB entries with the same primary citation |
| Experimental method | ELECTRON MICROSCOPY (2.2 Å) |
Structure validation
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