21TQ

The structure of Nav1.7 with veratridine standing near the IFM motif (site I)

This is a non-PDB format compatible entry.

Summary for 21TQ

• Entry DOI: 10.2210/pdb21tq/pdb
• EMDB information: 67991
• Descriptor: Sodium channel regulatory subunit beta-1, (5E,17R,20S)-23-amino-20-hydroxy-14,20-dioxo-15,19,21-trioxa-20lambda~5~-phosphatricos-5-en-17-yl hexadecanoate, Sodium channel regulatory subunit beta-2, ... (10 entities in total)
• Functional Keywords: nav1.7, voltage gated sodium channel, cryo-em, veratridine, site i, membrane protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 3
• Total formula weight: 271910.54

Authors

Fan, X.,Huang, J.,Yan, N. (deposition date: 2025-12-24, release date: 2026-03-11)

• Primary citation: Fan, X.,Chen, J.,Xue, L.,Wang, H.,Wu, T.,Huang, X.,Lu, F.,Jin, X.,Song, C.,Huang, J.,Yan, N.; Open-state structure of veratridine-activated human Nav1.7 reveals the molecular choreography of fast inactivation; To Be Published,

Experimental method

ELECTRON MICROSCOPY (2.7 Å)