21TK

Enterovirus 71 Polymerase (S417G mutant) Elongation Complex with Two Remdesivir Nucleotides Posing between Product Strand Positions -4/-5 and -6/-7, respectively (C3S6 form)

Summary for 21TK

• Entry DOI: 10.2210/pdb21tk/pdb
• Descriptor: Enterovirus 71 polymerase, RNA (34-MER), RNA (5'-R(*UP*GP*UP*UP*CP*GP*AP*CP*GP*AP*G*(F86)P*G*(F86)P*GP*CP*CP*U)-3'), ... (6 entities in total)
• Functional Keywords: enterovirus, rna-dependent rna polymerase, elongation complex, remdesivir nucleotide, transferase
• Biological source: Enterovirus A71; More
• Total number of polymer chains: 3
• Total formula weight: 70427.07

Authors

Li, R.,Gong, P. (deposition date: 2025-12-23, release date: 2026-10-07)

• Primary citation: Li, R.,Shao, Q.,Wang, M.,Feng, C.,Xu, Q.,Wang, Q.,Shang, L.; Highly effective viral RdRP translocation hindrance by the remdesivir nucleotide; Nucleic Acids Res., 2026; DOI: 10.1093/nar/gkag957

Experimental method

X-RAY DIFFRACTION (1.9 Å)