21TI

Enterovirus 71 Polymerase (S417G mutant) Elongation Complex with Remdesivir Nucleotides at Product Strand Positions -3 and -5 (C2S4 form)

Summary for 21TI

• Entry DOI: 10.2210/pdb21ti/pdb
• Descriptor: Enterovirus 71 polymerase, RNA (34-MER), RNA (5'-R(*UP*GP*UP*UP*CP*GP*AP*CP*GP*AP*G*(F86)P*G*(F86)P*GP*CP*C)-3'), ... (8 entities in total)
• Functional Keywords: enterovirus, rna-dependent rna polymerase, elongation complex, remdesivir nucleotide, transferase
• Biological source: Human enterovirus 71 (EV71, EV-71); More
• Total number of polymer chains: 3
• Total formula weight: 70502.80

Authors

Li, R.,Gong, P. (deposition date: 2025-12-23, release date: 2026-10-07)

• Primary citation: Li, R.,Shao, Q.,Wang, M.,Feng, C.,Xu, Q.,Wang, Q.,Shang, L.; Highly effective viral RdRP translocation hindrance by the remdesivir nucleotide; Nucleic Acids Res., 2026; DOI: 10.1093/nar/gkag957

Experimental method

X-RAY DIFFRACTION (2.22 Å)