21ET

1'-sugar-tethered cholesterol-modified siRNA

This is a non-PDB format compatible entry.

Summary for 21ET

• Entry DOI: 10.2210/pdb21et/pdb
• Descriptor: RNA (5'-R(*GP*GP*AP*CP*UP*CP*GP*AP*GP*UP*CP*CP*(LIG))-3'), SODIUM ION (3 entities in total)
• Functional Keywords: sirna, cholesterol, rna
• Biological source: synthetic construct
• Total number of polymer chains: 6
• Total formula weight: 26517.38

Authors

Kondo, J.,Ando, S.,Ueno, Y. (deposition date: 2025-12-10, release date: 2026-07-15)

• Primary citation: Shimada, Y.,Tsuchida, A.,Ando, S.,Kakisawa, Y.,Kohda, Y.,Ogata, A.,Mahmoud, E.M.,Kondo, J.,Sakamoto, S.,Ueno, Y.; 1'-Sugar-Tethered Cholesterol-Modified siRNAs with Variable Linker Lengths for Carrier-Free Delivery and Enhanced RNAi Efficiency; Acs Omega, 2026; DOI: 10.1021/acsomega.6c02915

Experimental method

X-RAY DIFFRACTION (2.8 Å)