21LT

Cryo-EM structure of the setmelanotide-bound human melanocortin receptor 4 (MC4R)-Gq complex

Summary for 21LT

• Entry DOI: 10.2210/pdb21lt/pdb
• EMDB information: 67804
• Descriptor: Setmelanotide, Melanocortin receptor 4,LgBiT subunit, G subunit q (Gi1-Gq chimeric), ... (6 entities in total)
• Functional Keywords: human melanocortin receptor 4, g protein-coupled receptor, setmelanotide, gq, membrane protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 5
• Total formula weight: 146505.39

Authors

Feng, W.B.,Zhou, Q.T.,Wang, M.W. (deposition date: 2025-12-17, release date: 2026-08-12)

• Primary citation: Feng, W.,Zhou, Q.,Wang, M.W.; Rationale of renewed efforts in developing MC4R modulators to treat metabolic disorders; Acta Pharm Sin B, 2026; DOI: 10.1016/j.apsb.2026.06.035

Experimental method

ELECTRON MICROSCOPY (3.11 Å)