1ZXV

X-Ray Crystal Structure of the Anthrax Lethal Factor Bound to a Small Molecule Inhibitor, BI-MFM3, 3-{5-[5-(4-Chloro-phenyl)-furan-2-ylmethylene]-4-oxo-2-thioxo-thiazolidin-3-yl}-propionic acid.

1ZXV の概要

• エントリーDOI: 10.2210/pdb1zxv/pdb
• 分子名称: lethal factor, ZINC ION, (E)-3-(5((5-(4-CHLOROPHENYL)FURAN-2-YL)METHYLENE)-4-OXO-2-THIOXOTHIAZOLIDIN-3-YL)PROPANOIC ACID (3 entities in total)
• 機能のキーワード: anthrax toxin lethal factor, protein and small molecule inhibitor complex, zinc metalloproteinase, hydrolase
• 由来する生物種: Bacillus anthracis
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 181632.17

構造登録者

Wong, T.Y.,Liddington, R.C. (登録日: 2005-06-08, 公開日: 2005-07-05, 最終更新日: 2024-03-13)

• 主引用文献: Forino, M.,Johnson, S.,Wong, T.Y.,Rozanov, D.V.,Savinov, A.Y.,Li, W.,Fattorusso, R.,Becattini, B.,Orry, A.J.,Jung, D.,Abagyan, R.A.,Smith, J.W.,Alibek, K.,Liddington, R.C.,Strongin, A.Y.,Pellecchia, M.; Efficient synthetic inhibitors of anthrax lethal factor.; Proc.Natl.Acad.Sci.Usa, 102:9499-9504, 2005; PubMed: 15983377; DOI: 10.1073/pnas.0502733102

実験手法

X-RAY DIFFRACTION (2.67 Å)