1ZXC

Crystal structure of catalytic domain of TNF-alpha converting enzyme (TACE) with inhibitor

Summary for 1ZXC

• Entry DOI: 10.2210/pdb1zxc/pdb
• Related: 1bkc
• Descriptor: ADAM 17, ZINC ION, (3S)-4-{[4-(BUT-2-YNYLOXY)PHENYL]SULFONYL}-N-HYDROXY-2,2-DIMETHYLTHIOMORPHOLINE-3-CARBOXAMIDE, ... (4 entities in total)
• Functional Keywords: tace/adam-17, tace-inhibitor complex, zn-endopeptidase, hydrolase
• Biological source: Homo sapiens (human)
• Cellular location: Membrane; Single-pass type I membrane protein: P78536
• Total number of polymer chains: 2
• Total formula weight: 60402.50

Authors

Levin, J.I.,Chen, J.M.,Laakso, L.M.,Du, M.,Schmid, J.,Xu, W.,Cummons, T.,Xu, J.,Zhang, Y.,Jin, G.,Cowling, R.,Barone, D.,Skotnicki, J.S. (deposition date: 2005-06-07, release date: 2005-09-27, Last modification date: 2023-08-23)

• Primary citation: Levin, J.I.,Chen, J.M.,Laakso, L.M.,Du, M.,Du, X.,Venkatesan, A.M.,Sandanayaka, V.,Zask, A.,Xu, J.,Xu, W.,Zhang, Y.,Skotnicki, J.S.; Acetylenic TACE inhibitors. Part 2: SAR of six-membered cyclic sulfonamide hydroxamates.; Bioorg.Med.Chem.Lett., 15:4345-4349, 2005; PubMed: 16084720; DOI: 10.1016/j.bmcl.2005.06.072

Experimental method

X-RAY DIFFRACTION (2.28 Å)