1ZXC
Crystal structure of catalytic domain of TNF-alpha converting enzyme (TACE) with inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | ADAM 17 | polymer | 263 | 29737.3 | 2 | UniProt (P78536) Pfam (PF13688) | Homo sapiens (human) | A disintegrin and metalloproteinase domain 17, TNF-alpha converting enzyme, TNF-alpha convertase, Snake venom-like protease, CD156b antigen |
| 2 | C, E (A, B) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 3 | D, F (A, B) | (3S)-4-{[4-(BUT-2-YNYLOXY)PHENYL]SULFONYL}-N-HYDROXY-2,2-DIMETHYLTHIOMORPHOLINE-3-CARBOXAMIDE | non-polymer | 398.5 | 2 | Chemie (IH6) | |||
| 4 | G, H (A, B) | water | water | 18.0 | 173 | Chemie (HOH) |
Sequence modifications
A, B: 215 - 477 (UniProt: P78536)
| PDB | External Database | Details |
|---|---|---|
| Ala 266 | Ser 266 | engineered mutation |
| Gln 452 | Asn 452 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 59474.7 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 927.8 | |
| All* | Total formula weight | 60402.5 |
