1ZTZ

Crystal structure of HIV protease- metallacarborane complex

Summary for 1ZTZ

• Entry DOI: 10.2210/pdb1ztz/pdb
• Related: 1NH0
• Descriptor: PROTEASE RETROPEPSIN, autoproteolytic tetrapeptide, COBALT BIS(1,2-DICARBOLLIDE), ... (4 entities in total)
• Functional Keywords: rational drug design; hiv protease inhibitors; aspartic proteases; carboranes; metallacarboranes, hydrolase
• Biological source: Human immunodeficiency virus 1
• Cellular location: Gag-Pol polyprotein: Host cell membrane ; Lipid-anchor. Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P03367
• Total number of polymer chains: 3
• Total formula weight: 22545.41

Authors

Cigler, P.,Kozisek, M.,Rezacova, P.,Brynda, J.,Otwinowski, Z.,Sedlacek, J.,Bodem, J.,Kraeusslich, H.-G.,Kral, V.,Konvalinka, J. (deposition date: 2005-05-28, release date: 2005-11-01, Last modification date: 2023-08-23)

• Primary citation: Cigler, P.,Kozisek, M.,Rezacova, P.,Brynda, J.,Otwinowski, Z.,Pokorna, J.,Plesek, J.,Gruner, B.,Doleckova-Maresova, L.,Masa, M.,Sedlacek, J.,Bodem, J.,Kraeusslich, H.-G.,Kral, V.,Konvalinka, J.; From nonpeptide toward noncarbon protease inhibitors: Metallacarboranes as specific and potent inhibitors of HIV protease; Proc.Natl.Acad.Sci.USA, 102:15394-15399, 2005; PubMed: 16227435; DOI: 10.1073/pnas.0507577102

Experimental method

X-RAY DIFFRACTION (2.15 Å)