1ZTZ

Crystal structure of HIV protease- metallacarborane complex

1ZTZ の概要

• エントリーDOI: 10.2210/pdb1ztz/pdb
• 関連するPDBエントリー: 1NH0
• 分子名称: PROTEASE RETROPEPSIN, autoproteolytic tetrapeptide, COBALT BIS(1,2-DICARBOLLIDE), ... (4 entities in total)
• 機能のキーワード: rational drug design; hiv protease inhibitors; aspartic proteases; carboranes; metallacarboranes, hydrolase
• 由来する生物種: Human immunodeficiency virus 1
• 細胞内の位置: Gag-Pol polyprotein: Host cell membrane ; Lipid-anchor. Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P03367
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 22545.41

構造登録者

Cigler, P.,Kozisek, M.,Rezacova, P.,Brynda, J.,Otwinowski, Z.,Sedlacek, J.,Bodem, J.,Kraeusslich, H.-G.,Kral, V.,Konvalinka, J. (登録日: 2005-05-28, 公開日: 2005-11-01, 最終更新日: 2023-08-23)

• 主引用文献: Cigler, P.,Kozisek, M.,Rezacova, P.,Brynda, J.,Otwinowski, Z.,Pokorna, J.,Plesek, J.,Gruner, B.,Doleckova-Maresova, L.,Masa, M.,Sedlacek, J.,Bodem, J.,Kraeusslich, H.-G.,Kral, V.,Konvalinka, J.; From nonpeptide toward noncarbon protease inhibitors: Metallacarboranes as specific and potent inhibitors of HIV protease; Proc.Natl.Acad.Sci.USA, 102:15394-15399, 2005; PubMed: 16227435; DOI: 10.1073/pnas.0507577102

実験手法

X-RAY DIFFRACTION (2.15 Å)