1ZRB

Thrombin in complex with an azafluorenyl inhibitor 23b

1ZRB の概要

• エントリーDOI: 10.2210/pdb1zrb/pdb
• 分子名称: thrombin, 11-peptide hirudin fragment, 3-AZA-9-HYDROXY-9-FLUORENYLCARBONYL-L-PROLYL-2-AMINOMETHYL-5-CHLOROBENZYLAMIDE, N-OXIDE, ... (4 entities in total)
• 機能のキーワード: thrombin; thrombin inhibitor complex, blood clotting, hydrolase-inhibitor complex, hydrolase/inhibitor
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Secreted, extracellular space: P00734; Secreted: P28504
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 35064.45

構造登録者

Stauffer, K.J.,Williams, P.D.,Selnick, H.G.,Nantermet, P.G.,Newton, C.L.,Homnick, C.F.,Zrada, M.M.,Lewis, S.D.,Lucas, B.J.,Krueger, J.A.,Pietrak, B.L.,Lyle, E.A.,Singh, R.,Miller-Stein, C.,White, R.B.,Wong, B.,Wallace, A.A.,Sitko, G.R.,Cook, J.J.,Holahan, M.A.,Stranieri-Michener, M.,Leonard, Y.M.,Lynch Jr., J.J.,McMasters, D.R.,Yan, Y. (登録日: 2005-05-19, 公開日: 2005-06-07, 最終更新日: 2013-03-13)

• 主引用文献: Stauffer, K.J.,Williams, P.D.,Selnick, H.G.,Nantermet, P.G.,Newton, C.L.,Homnick, C.F.,Zrada, M.M.,Lewis, S.D.,Lucas, B.J.,Krueger, J.A.,Pietrak, B.L.,Lyle, E.A.,Singh, R.,Miller-Stein, C.,White, R.B.,Wong, B.,Wallace, A.A.,Sitko, G.R.,Cook, J.J.,Holahan, M.A.,Stranieri-Michener, M.,Leonard, Y.M.,Lynch Jr., J.J.,McMasters, D.R.,Yan, Y.; 9-hydroxyazafluorenes and their use in thrombin inhibitors; J.Med.Chem., 48:2282-2293, 2005; PubMed: 15801822; DOI: 10.1021/jm049423s

実験手法

X-RAY DIFFRACTION (1.9 Å)