1ZOS

Structure of 5'-methylthionadenosine/S-Adenosylhomocysteine nucleosidase from S. pneumoniae with a transition-state inhibitor MT-ImmA

1ZOS の概要

• エントリーDOI: 10.2210/pdb1zos/pdb
• 分子名称: 5'-methylthioadenosine / S-adenosylhomocysteine nucleosidase, (3S,4R)-2-(4-AMINO-5H-PYRROLO[3,2-D]PYRIMIDIN-7-YL)-5-[(METHYLSULFANYL)METHYL]PYRROLIDINE-3,4-DIOL (3 entities in total)
• 機能のキーワード: nucleosidase, pneumoniae, transition state, inhibitor, hydrolase
• 由来する生物種: Streptococcus pneumoniae R6
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 149983.92

構造登録者

Shi, W.,Singh, V.,Zhen, R.,Tyler, P.C.,Furneaux, R.H.,Almo, S.C.,Schramm, V.L. (登録日: 2005-05-13, 公開日: 2006-04-25, 最終更新日: 2023-08-23)

• 主引用文献: Singh, V.,Shi, W.,Almo, S.C.,Evans, G.B.,Furneaux, R.H.,Tyler, P.C.,Painter, G.F.,Lenz, D.H.,Mee, S.,Zheng, R.,Schramm, V.L.; Structure and inhibition of a quorum sensing target from Streptococcus pneumoniae.; Biochemistry, 45:12929-12941, 2006; PubMed: 17059210; DOI: 10.1021/bi061184i

実験手法

X-RAY DIFFRACTION (1.6 Å)