1ZNB

METALLO-BETA-LACTAMASE

1ZNB の概要

• エントリーDOI: 10.2210/pdb1znb/pdb
• 分子名称: METALLO-BETA-LACTAMASE, ZINC ION, SODIUM ION, ... (4 entities in total)
• 機能のキーワード: hydrolase (beta-lactamase), metallo beta-lactamase zinc
• 由来する生物種: Bacteroides fragilis
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 50848.60

構造登録者

Concha, N.O.,Herzberg, O. (登録日: 1996-06-06, 公開日: 1997-01-11, 最終更新日: 2024-02-14)

主引用文献

Concha, N.O.,Rasmussen, B.A.,Bush, K.,Herzberg, O.
Crystal structure of the wide-spectrum binuclear zinc beta-lactamase from Bacteroides fragilis.
Structure, 4:823-836, 1996

PubMed Abstract: The metallo-beta-lactamase from Bacteroides fragilis hydrolyzes a wide range of beta-lactam antibiotics, and is not clinically susceptible to any known beta-lactamase inhibitors. B. fragilis is associated with post-surgery hospital infections, and there has been a recent report of plasmid-mediated dissemination of the enzyme. Effective inhibitors are therefore urgently needed. Knowledge of the three-dimensional structure will aid in the drug design effort.

PubMed: 8805566
DOI: 10.1016/S0969-2126(96)00089-5

実験手法

X-RAY DIFFRACTION (1.85 Å)