1ZHP

Crystal Structure of the Catalytic Domain of Coagulation Factor XI in Complex with Benzamidine (S434A-T475A-K505 Mutant)

1ZHP の概要

• エントリーDOI: 10.2210/pdb1zhp/pdb
• 関連するPDBエントリー: 1ZHM 1ZHR 1ZJD
• 分子名称: coagulation factor XI, BENZAMIDINE, GLUTATHIONE, ... (4 entities in total)
• 機能のキーワード: factor xi; benzamidine, hydrolase, blood clotting
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Secreted: P03951
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 27195.91

構造登録者

Jin, L.,Pandey, P.,Babine, R.E.,Weaver, D.T.,Abdel-Meguid, S.S.,Strickler, J.E. (登録日: 2005-04-26, 公開日: 2005-09-20, 最終更新日: 2023-08-23)

• 主引用文献: Jin, L.,Pandey, P.,Babine, R.E.,Weaver, D.T.,Abdel-Meguid, S.S.,Strickler, J.E.; Mutation of surface residues to promote crystallization of activated factor XI as a complex with benzamidine: an essential step for the iterative structure-based design of factor XI inhibitors.; Acta Crystallogr.,Sect.D, 61:1418-1425, 2005; PubMed: 16204896; DOI: 10.1107/S0907444905024340

実験手法

X-RAY DIFFRACTION (2.7 Å)