1ZHP
Crystal Structure of the Catalytic Domain of Coagulation Factor XI in Complex with Benzamidine (S434A-T475A-K505 Mutant)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | coagulation factor XI | polymer | 238 | 26768.4 | 1 | UniProt (P03951) Pfam (PF00089) In PDB | Homo sapiens (human) | Plasma thromboplastin antecedent; PTA; FXI |
| 2 | A | BENZAMIDINE | non-polymer | 120.2 | 1 | Chemie (BEN) | |||
| 3 | A | GLUTATHIONE | non-polymer | 307.3 | 1 | Chemie (GSH) | |||
| 4 | water | water | 18.0 | 53 | Chemie (HOH) |
Sequence modifications
A: 16 - 245 (UniProt: P03951)
| PDB | External Database | Details |
|---|---|---|
| Ala 75 | Ser 452 | engineered mutation |
| Ala 115 | Thr 493 | engineered mutation |
| Ala 145 | Lys 523 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 26768.4 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 427.5 | |
| All* | Total formula weight | 27195.9 |
