1ZEO

Crystal Structure of Human PPAR-gamma Ligand Binding Domain Complexed with an Alpha-Aryloxyphenylacetic Acid Agonist

1ZEO の概要

• エントリーDOI: 10.2210/pdb1zeo/pdb
• 分子名称: Peroxisome proliferator activated receptor gamma, (2S)-(4-ISOPROPYLPHENYL)[(2-METHYL-3-OXO-5,7-DIPROPYL-2,3-DIHYDRO-1,2-BENZISOXAZOL-6-YL)OXY]ACETATE (3 entities in total)
• 機能のキーワード: nuclear receptor, ligand binding domain, lbd, alpha helix sandwich, ppar-rxr heterodimer, transcription
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Nucleus: P37231
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 63611.81

構造登録者

Shi, G.Q.,Dropinski, J.F.,McKeever, B.M.,Adams, A.D.,MacNaul, K.L.,Elbrecht, A.,Berger, J.P.,Zhou, G.,Doebber, T.W. (登録日: 2005-04-19, 公開日: 2006-04-25, 最終更新日: 2024-04-03)

• 主引用文献: Shi, G.Q.,Dropinski, J.F.,McKeever, B.M.,Xu, S.,Becker, J.W.,Berger, J.P.,MacNaul, K.L.,Elbrecht, A.,Zhou, G.,Doebber, T.W.,Wang, P.,Chao, Y.-S.,Forrest, M.,Heck, J.V.,Moller, D.E.,Jones, B.A.; Design and Synthesis of alpha-Aryloxyphenylacetic Acid Derivatives: A Novel Class of PPAR alpha/gamma Dual Agonists with Potent Antihyperglycemic and Lipid Modulating Activity; J.Med.Chem., 48:4457-4468, 2005; PubMed: 15974597; DOI: 10.1021/jm0502135

実験手法

X-RAY DIFFRACTION (2.5 Å)