1Z8G

Crystal structure of the extracellular region of the transmembrane serine protease hepsin with covalently bound preferred substrate.

1Z8G の概要

• エントリーDOI: 10.2210/pdb1z8g/pdb
• 関連するBIRD辞書のPRD_ID: PRD_000307
• 分子名称: Serine protease hepsin, ACE-LYS-GLN-LEU-ARG-Chloromethylketone (3 entities in total)
• 機能のキーワード: serine protease hepsin, protease, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Membrane; Single-pass type II membrane protein: P05981
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 41054.97

構造登録者

Herter, S.,Piper, D.E.,Aaron, W.,Gabriele, T.,Cutler, G.,Cao, P.,Bhatt, A.S.,Choe, Y.,Craik, C.S.,Walker, N.,Meininger, D.,Hoey, T.,Austin, R.J. (登録日: 2005-03-30, 公開日: 2005-05-03, 最終更新日: 2023-08-23)

• 主引用文献: Herter, S.,Piper, D.E.,Aaron, W.,Gabriele, T.,Cutler, G.,Cao, P.,Bhatt, A.S.,Choe, Y.,Craik, C.S.,Walker, N.,Meininger, D.,Hoey, T.,Austin, R.J.; Hepatocyte growth factor is a preferred in vitro substrate for human hepsin, a membrane-anchored serine protease implicated in prostate and ovarian cancers; Biochem.J., 390:125-136, 2005; PubMed: 15839837; DOI: 10.1042/BJ20041955

実験手法

X-RAY DIFFRACTION (1.55 Å)