1Z6J

Crystal Structure of a ternary complex of Factor VIIa/Tissue Factor/Pyrazinone Inhibitor

Summary for 1Z6J

Entry DOI	10.2210/pdb1z6j/pdb
Descriptor	Coagulation factor VII, Tissue factor, CALCIUM ION, ... (7 entities in total)
Functional Keywords	blood coagulation, serine protease, thrombosis, gla, pyrazinone, benzamidine, tissue factor, cofactor, enzyme inhibitor complex, hydrolase
Biological source	Homo sapiens (human) More
Total number of polymer chains	3
Total formula weight	69040.68
Authors	Schweitzer, B.A.,Neumann, W.L.,Rahman, H.K.,Kusturin, C.L.,Sample, K.R.,Poda, G.I.,Kurumbail, R.G.,Stevens, A.M.,Stegeman, R.A.,Stallings, W.C. (deposition date: 2005-03-22, release date: 2005-05-03, Last modification date: 2019-07-24)
Primary citation	Schweitzer, B.A.,Neumann, W.L.,Rahman, H.K.,Kusturin, C.L.,Sample, K.R.,Poda, G.I.,Kurumbail, R.G.,Stevens, A.M.,Stegeman, R.A.,Stallings, W.C.,South, M.S. Structure-based design and synthesis of pyrazinones containing novel P1 'side pocket' moieties as inhibitors of TF/VIIa. Bioorg.Med.Chem.Lett., 15:3006-3011, 2005 Cited by PubMed: 15913999 DOI: 10.1016/j.bmcl.2005.04.037 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation