1Z6J
Crystal Structure of a ternary complex of Factor VIIa/Tissue Factor/Pyrazinone Inhibitor
Summary for 1Z6J
Entry DOI | 10.2210/pdb1z6j/pdb |
Descriptor | Coagulation factor VII, Tissue factor, CALCIUM ION, ... (7 entities in total) |
Functional Keywords | blood coagulation, serine protease, thrombosis, gla, pyrazinone, benzamidine, tissue factor, cofactor, enzyme inhibitor complex, hydrolase |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 3 |
Total formula weight | 69040.68 |
Authors | Schweitzer, B.A.,Neumann, W.L.,Rahman, H.K.,Kusturin, C.L.,Sample, K.R.,Poda, G.I.,Kurumbail, R.G.,Stevens, A.M.,Stegeman, R.A.,Stallings, W.C. (deposition date: 2005-03-22, release date: 2005-05-03, Last modification date: 2019-07-24) |
Primary citation | Schweitzer, B.A.,Neumann, W.L.,Rahman, H.K.,Kusturin, C.L.,Sample, K.R.,Poda, G.I.,Kurumbail, R.G.,Stevens, A.M.,Stegeman, R.A.,Stallings, W.C.,South, M.S. Structure-based design and synthesis of pyrazinones containing novel P1 'side pocket' moieties as inhibitors of TF/VIIa. Bioorg.Med.Chem.Lett., 15:3006-3011, 2005 Cited by PubMed: 15913999DOI: 10.1016/j.bmcl.2005.04.037 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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