1Z58

Crystal structure of a complex of the ribosome large subunit with rapamycin

1Z58 の概要

• エントリーDOI: 10.2210/pdb1z58/pdb
• 関連するPDBエントリー: 1nkw 1ond 1p9x
• 分子名称: 23S RIBOSOMAL RNA, RAPAMYCIN IMMUNOSUPPRESSANT DRUG (2 entities in total)
• 機能のキーワード: ribosome, tunnel, polyketyde
• 由来する生物種: Deinococcus radiodurans
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 934319.17

構造登録者

Amit, M.,Berisio, R.,Baram, D.,Harms, J.,Bashan, A.,Yonath, A. (登録日: 2005-03-17, 公開日: 2005-06-28, 最終更新日: 2024-02-14)

主引用文献

Amit, M.,Berisio, R.,Baram, D.,Harms, J.,Bashan, A.,Yonath, A.
A crevice adjoining the ribosome tunnel: Hints for cotranslational folding.
Febs Lett., 579:3207-3213, 2005

PubMed Abstract: RNA protection experiments and the crystal structure of a complex of the large ribosomal subunit from the eubacterium Deinococcus radiodurans with rapamycin, a polyketide compound resembling macrolides and ketolides, showed that rapamycin binds to a crevice located at the boundaries of the nascent protein exit tunnel, near its entrance. At this location rapamycin cannot occlude the ribosome exit tunnel, consistent with its failure to act as a ribosomal antibiotic drug. In accord with recent biochemical data, this crevice may play a role in facilitating local cotranslational folding of nascent chains, in particular for transmembrane proteins.

PubMed: 15943964
DOI: 10.1016/j.febslet.2005.03.023

実験手法

X-RAY DIFFRACTION (3.8 Å)