1P9X

THE CRYSTAL STRUCTURE OF THE 50S LARGE RIBOSOMAL SUBUNIT FROM DEINOCOCCUS RADIODURANS COMPLEXED WITH TELITHROMYCIN KETOLIDE ANTIBIOTIC

Summary for 1P9X

Entry DOI	10.2210/pdb1p9x/pdb
Related	1JZX 1JZY 1NJM 1NJN 1NKW 1OND
Descriptor	23S RIBOSOMAL RNA, TELITHROMYCIN (2 entities in total)
Functional Keywords	ribosomes, trna, ketolide, macrolide, antibiotic, exit-tunnel, blockage, ribosome
Biological source	Deinococcus radiodurans
Total number of polymer chains	1
Total formula weight	934217.00
Authors	Berisio, R.,Harms, J.,Schluenzen, F.,Zarivach, R.,Hansen, H.A.,Fucini, P.,Yonath, A. (deposition date: 2003-05-13, release date: 2003-08-05, Last modification date: 2023-08-16)
Primary citation	Berisio, R.,Harms, J.,Schluenzen, F.,Zarivach, R.,Hansen, H.A.,Fucini, P.,Yonath, A. Structural insight into the antibiotic action of telithromycin against resistant mutants J.Bacteriol., 185:4276-4279, 2003 Cited by PubMed Abstract: The crystal structure of the ketolide telithromycin bound to the Deinococcus radiodurans large ribosomal subunit shows that telithromycin blocks the ribosomal exit tunnel and interacts with domains II and V of the 23S RNA. Comparisons to other clinically relevant macrolides provided structural insights into its enhanced activity against macrolide-resistant strains. PubMed: 12837804 DOI: 10.1128/JB.185.14.4276-4279.2003 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.4 Å)

Structure validation