1Z3G

Crystal structure of complex between Pvs25 and Fab fragment of malaria transmission blocking antibody 2A8

Summary for 1Z3G

Entry DOI	10.2210/pdb1z3g/pdb
Descriptor	2A8 Fab Light Chain, 2A8 Fab Heavy Chain, ookinete surface protein Pvs25 (3 entities in total)
Functional Keywords	2a8 fab, pvs25, immune system-cell adhesion complex, immune system/cell adhesion
Biological source	Mus musculus (house mouse) More
Total number of polymer chains	6
Total formula weight	134212.03
Authors	Saxena, A.K.,Singh, K.,Su, H.P.,Klein, M.M.,Stowers, A.W.,Saul, A.J.,Long, C.A.,Garboczi, D.N. (deposition date: 2005-03-12, release date: 2005-12-06, Last modification date: 2024-10-30)
Primary citation	Saxena, A.K.,Singh, K.,Su, H.P.,Klein, M.M.,Stowers, A.W.,Saul, A.J.,Long, C.A.,Garboczi, D.N. The essential mosquito-stage P25 and P28 proteins from Plasmodium form tile-like triangular prisms Nat.Struct.Mol.Biol., 13:90-91, 2006 Cited by PubMed Abstract: P25 and P28 proteins are essential for Plasmodium parasites to infect mosquitoes and are leading candidates for a transmission-blocking malaria vaccine. The Plasmodium vivax P25 is a triangular prism that could tile the parasite surface. The residues forming the triangle are conserved in P25 and P28 from all Plasmodium species. A cocrystal structure shows that a transmission-blocking antibody uses only its heavy chain to bind Pvs25 at a vertex of the triangle. PubMed: 16327807 DOI: 10.1038/nsmb1024 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.3 Å)

Structure validation