1Z1Y

Crystal structure of Methylated Pvs25, an ookinete protein from Plasmodium vivax

Summary for 1Z1Y

• Entry DOI: 10.2210/pdb1z1y/pdb
• Descriptor: ookinete surface protein Pvs25, YTTERBIUM (III) ION (3 entities in total)
• Functional Keywords: four egf-like domains, cell adhesion
• Biological source: Plasmodium vivax (malaria parasite P. vivax)
• Total number of polymer chains: 2
• Total formula weight: 43627.50

Authors

Saxena, A.K.,Singh, K.,Su, H.P.,Klein, M.M.,Stowers, A.W.,Saul, A.J.,Long, C.A.,Garboczi, D.N. (deposition date: 2005-03-07, release date: 2005-12-06, Last modification date: 2019-11-20)

Primary citation

Saxena, A.K.,Singh, K.,Su, H.P.,Klein, M.M.,Stowers, A.W.,Saul, A.J.,Long, C.A.,Garboczi, D.N.
The essential mosquito-stage P25 and P28 proteins from Plasmodium form tile-like triangular prisms
Nat.Struct.Mol.Biol., 13:90-91, 2006

PubMed Abstract: P25 and P28 proteins are essential for Plasmodium parasites to infect mosquitoes and are leading candidates for a transmission-blocking malaria vaccine. The Plasmodium vivax P25 is a triangular prism that could tile the parasite surface. The residues forming the triangle are conserved in P25 and P28 from all Plasmodium species. A cocrystal structure shows that a transmission-blocking antibody uses only its heavy chain to bind Pvs25 at a vertex of the triangle.

PubMed: 16327807
DOI: 10.1038/nsmb1024

Experimental method

X-RAY DIFFRACTION (2 Å)