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1YZ3

Structure of human pnmt complexed with cofactor product adohcy and inhibitor SK&F 64139

Summary for 1YZ3
Entry DOI10.2210/pdb1yz3/pdb
Related1HNN 1N7I 1N7J
DescriptorPhenylethanolamine N-methyltransferase, 7,8-DICHLORO-1,2,3,4-TETRAHYDROISOQUINOLINE, S-ADENOSYL-L-HOMOCYSTEINE, ... (4 entities in total)
Functional Keywordsenzyme, product, inhibitor complex, transferase
Biological sourceHomo sapiens (human)
Total number of polymer chains2
Total formula weight64864.92
Authors
Wu, Q.,Gee, C.L.,Lin, F.,Martin, J.L.,Grunewald, G.L.,McLeish, M.J. (deposition date: 2005-02-27, release date: 2006-02-07, Last modification date: 2023-10-25)
Primary citationWu, Q.,Gee, C.L.,Lin, F.,Tyndall, J.D.,Martin, J.L.,Grunewald, G.L.,McLeish, M.J.
Structural, mutagenic, and kinetic analysis of the binding of substrates and inhibitors of human phenylethanolamine N-methyltransferase
J.Med.Chem., 48:7243-7252, 2005
Cited by
PubMed: 16279783
DOI: 10.1021/jm050568o
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.4 Å)
Structure validation

217705

건을2024-03-27부터공개중

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