1YY9
Structure of the extracellular domain of the epidermal growth factor receptor in complex with the Fab fragment of cetuximab/Erbitux/IMC-C225
Summary for 1YY9
Entry DOI | 10.2210/pdb1yy9/pdb |
Related | 1YY8 |
Descriptor | Epidermal Growth Factor Receptor, Cetuximab Fab Light chain, Cetuximab Fab Heavy chain, ... (7 entities in total) |
Functional Keywords | cell surface receptor; tyrosine kinase; glycoprotein; antigen:antibody complex; fab fragment; antitumor; drug, immune system-transferase complex, immune system/transferase |
Biological source | Homo sapiens (human) More |
Cellular location | Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted: P00533 |
Total number of polymer chains | 3 |
Total formula weight | 120235.81 |
Authors | Li, S.,Schmitz, K.R.,Jeffrey, P.D.,Wiltzius, J.J.W.,Kussie, P.,Ferguson, K.M. (deposition date: 2005-02-24, release date: 2005-04-26, Last modification date: 2023-08-23) |
Primary citation | Li, S.,Schmitz, K.R.,Jeffrey, P.D.,Wiltzius, J.J.W.,Kussie, P.,Ferguson, K.M. Structural basis for inhibition of the epidermal growth factor receptor by cetuximab Cancer Cell, 7:301-311, 2005 Cited by PubMed: 15837620DOI: 10.1016/j.ccr.2005.03.003 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.605 Å) |
Structure validation
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