1YVF

Hepatitis C virus NS5B RNA-dependent RNA polymerase complex with inhibitor PHA-00729145

Summary for 1YVF

Entry DOI	10.2210/pdb1yvf/pdb
Descriptor	HCV NS5B POLYMERASE, PHOSPHATE ION, CHLORIDE ION, ... (6 entities in total)
Functional Keywords	ns5b, polymerase, hcv, fingers, palm, thumb, transferase
Biological source	Hepatitis C virus
Total number of polymer chains	1
Total formula weight	65319.13
Authors	Pfefferkorn, J.A.,Greene, M.L.,Nugent, R.A.,Gross, R.J.,Mitchell, M.A.,Finzel, B.C.,Harris, M.S.,Wells, P.A.,Shelly, J.A.,Anstadt, R.A.,Kilkuskie, R.E.,Kopta, L.A.,Schwende, F.J. (deposition date: 2005-02-15, release date: 2005-04-19, Last modification date: 2024-02-14)
Primary citation	Pfefferkorn, J.A.,Greene, M.L.,Nugent, R.A.,Gross, R.J.,Mitchell, M.A.,Finzel, B.C.,Harris, M.S.,Wells, P.A.,Shelly, J.A.,Anstadt, R.A.,Kilkuskie, R.E.,Kopta, L.A.,Schwende, F.J. Inhibitors of HCV NS5B polymerase. Part 1: Evaluation of the southern region of (2Z)-2-(benzoylamino)-3-(5-phenyl-2-furyl)acrylic acid. Bioorg.Med.Chem.Lett., 15:2481-2486, 2005 Cited by PubMed: 15863301 DOI: 10.1016/j.bmcl.2005.03.066 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation