1YTF

YEAST TFIIA/TBP/DNA COMPLEX

1YTF の概要

• エントリーDOI: 10.2210/pdb1ytf/pdb
• 分子名称: DNA (5'-D(*TP*GP*TP*AP*TP*GP*TP*AP*TP*AP*TP*AP*AP*AP*AP*C)-3'), DNA (5'-D(*GP*TP*TP*TP*TP*AP*TP*AP*TP*AP*CP*AP*TP*AP*CP*A)-3'), PROTEIN (TATA BINDING PROTEIN (TBP)), ... (6 entities in total)
• 機能のキーワード: transcription regulation, dna, complex, transcription-dna complex, transcription/dna
• 由来する生物種: Saccharomyces cerevisiae (baker's yeast); 詳細
• 細胞内の位置: Nucleus: P13393; Cytoplasm: P32773 P32773 P32774
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 58305.47

構造登録者

Tan, S.,Hunziker, Y.,Sargent, D.F.,Richmond, T.J. (登録日: 1996-04-05, 公開日: 1996-06-20, 最終更新日: 2024-02-14)

主引用文献

Tan, S.,Hunziker, Y.,Sargent, D.F.,Richmond, T.J.
Crystal structure of a yeast TFIIA/TBP/DNA complex.
Nature, 381:127-134, 1996

PubMed Abstract: The X-ray crystal structure of the transcription factor IIA (TFIIA) in complex with the TATA-box-binding protein (TBP) and TATA-element DNA is presented at 2.5 A resolution. TFIIA is composed of a beta-barrel and a four-helix bundle motif that together have a boot-like appearance. The beta-barrel extends the TBP beta-sheet and bridges over the DNA major groove immediately upstream of the TATA box. The four-helix bundle contributes substantially to the surface of the complex available for interaction with additional transcription factors.

PubMed: 8610010
DOI: 10.1038/381127a0

実験手法

X-RAY DIFFRACTION (2.5 Å)