1YRK

The C2 Domain of PKC is a new Phospho-Tyrosine Binding Domain

1YRK の概要

• エントリーDOI: 10.2210/pdb1yrk/pdb
• 関連するPDBエントリー: 1BDY
• 分子名称: Protein kinase C, delta type, 13-residue peptide, ACETIC ACID, ... (4 entities in total)
• 機能のキーワード: c2 domain, protein binding
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Cytoplasm (By similarity): Q05655
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 15993.29

構造登録者

Benes, C.H.,Wu, N.,Elia, A.E.,Dharia, T.,Cantley, L.C.,Soltoff, S.P. (登録日: 2005-02-03, 公開日: 2005-07-26, 最終更新日: 2011-07-13)

主引用文献

Benes, C.H.,Wu, N.,Elia, A.E.,Dharia, T.,Cantley, L.C.,Soltoff, S.P.
The C2 domain of PKCdelta is a phosphotyrosine binding domain.
Cell(Cambridge,Mass.), 121:271-280, 2005

PubMed Abstract: In this issue of Cell, report that the C2 domain of the serine/threonine protein kinase Cdelta is a phosphotyrosine binding domain and present the crystal structure of this C2 domain bound to a peptide containing phosphotyrosine. Prior to this work, C2 domains were thought to bind only to phospholipids or to unphosphorylated proteins, and the SH2 and PTB domains were the only signaling domains known to recognize phosphotyrosine. This new role for the C2 domain links phosphotyrosine recognition directly to serine/threonine kinase activity and reveals an unexpected mechanism for crosstalk between distinct signaling pathways.

PubMed: 15851022
DOI: 10.1016/j.cell.2005.02.019

実験手法

X-RAY DIFFRACTION (1.7 Å)