1YPM

X-ray crystal structure of thrombin inhibited by synthetic cyanopeptide analogue RA-1014

Summary for 1YPM

• Entry DOI: 10.2210/pdb1ypm/pdb
• Related: 1YPL
• Descriptor: thrombin light chain, Thrombin heavy chain, Hirudin, ... (5 entities in total)
• Functional Keywords: thrombin, inhibitor complex, barrel, 6 stranded beta-sheet, blood clotting-hydrolase inhibitor complex, blood clotting/hydrolase inhibitor
• Biological source: Homo sapiens (human); More
• Cellular location: Secreted, extracellular space: P00734 P00734; Secreted: P28504
• Total number of polymer chains: 3
• Total formula weight: 34635.65

Authors

Fokkens, J.,Radau, G. (deposition date: 2005-01-31, release date: 2006-01-17, Last modification date: 2017-10-11)

• Primary citation: Radau, G.,Fokkens, J.; Design and X-ray crystal structures of human thrombin with synthetic cyanopeptide-analogues.; Pharmazie, 62:83-88, 2007; PubMed: 17341023

Experimental method

X-RAY DIFFRACTION (1.85 Å)