3JUH

Crystal structure of a mutant of human protein kinase CK2alpha with altered cosubstrate specificity

Replaces:  3BW5Replaces:  1YMI

Summary for 3JUH

• Entry DOI: 10.2210/pdb3juh/pdb
• Related: 1JWH 1LP4 2PVR 3FWQ 3H30
• Descriptor: Casein kinase II subunit alpha, CHLORIDE ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... (5 entities in total)
• Functional Keywords: eukaryotic protein kinase, atp-binding, kinase, nucleotide-binding, phosphoprotein, serine/threonine-protein kinase, transferase, wnt signaling pathway
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 81450.60

Authors

Niefind, K.,Issinger, O.-G. (deposition date: 2009-09-15, release date: 2009-10-20, Last modification date: 2024-03-20)

• Primary citation: Yde, C.W.,Ermakova, I.,Issinger, O.-G.,Niefind, K.; Inclining the purine base binding plane in protein kinase CK2 by exchanging the flanking side-chains generates a preference for ATP as a cosubstrate; J.Mol.Biol., 347:399-414, 2005; PubMed: 15740749; DOI: 10.1016/j.jmb.2005.01.003

Experimental method

X-RAY DIFFRACTION (1.66 Å)