3JUH
Crystal structure of a mutant of human protein kinase CK2alpha with altered cosubstrate specificity
Replaces: 3BW5Replaces: 1YMISummary for 3JUH
Entry DOI | 10.2210/pdb3juh/pdb |
Related | 1JWH 1LP4 2PVR 3FWQ 3H30 |
Descriptor | Casein kinase II subunit alpha, CHLORIDE ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... (5 entities in total) |
Functional Keywords | eukaryotic protein kinase, atp-binding, kinase, nucleotide-binding, phosphoprotein, serine/threonine-protein kinase, transferase, wnt signaling pathway |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 81450.60 |
Authors | Niefind, K.,Issinger, O.-G. (deposition date: 2009-09-15, release date: 2009-10-20, Last modification date: 2024-03-20) |
Primary citation | Yde, C.W.,Ermakova, I.,Issinger, O.-G.,Niefind, K. Inclining the purine base binding plane in protein kinase CK2 by exchanging the flanking side-chains generates a preference for ATP as a cosubstrate J.Mol.Biol., 347:399-414, 2005 Cited by PubMed: 15740749DOI: 10.1016/j.jmb.2005.01.003 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.66 Å) |
Structure validation
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