3JUH

Crystal structure of a mutant of human protein kinase CK2alpha with altered cosubstrate specificity

Replaces:  3BW5Replaces:  1YMI

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Casein kinase II subunit alpha	polymer	335	40020.7	2	UniProt (P68400) Pfam (PF00069) In PDB	Homo sapiens (human)	CK II
2	A, B	CHLORIDE ION	non-polymer		35.5	6	Chemie (CL)
3	A, B	PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER	non-polymer		506.2	2	Chemie (ANP)
4	A, B	GLYCEROL	non-polymer		92.1	2	Chemie (GOL)
5		water	water		18.0	518	Chemie (HOH)

Sequence modifications

A, B: 1 - 335 (UniProt: P68400)

PDB	External Database	Details
Ala 66	Val 66	engineered mutation
Leu 163	Met 163	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	80041.3
Non-Polymers*	Number of molecules	10
	Total formula weight	1409.3
All*	Total formula weight	81450.6

*Water molecules are not included.