1YK8

Cathepsin K complexed with a cyanamide-based inhibitor

Summary for 1YK8

Entry DOI	10.2210/pdb1yk8/pdb
Descriptor	Cathepsin K, TERT-BUTYL 2-CYANO-2-METHYLHYDRAZINECARBOXYLATE (3 entities in total)
Functional Keywords	catk, cathepsin, cysteine, protease, hydrolase
Biological source	Homo sapiens (human)
Cellular location	Lysosome: P43235
Total number of polymer chains	1
Total formula weight	23694.68
Authors	Barrett, D.G.,Deaton, D.N.,Hassell, A.M.,McFadyen, R.B.,Miller, A.B.,Miller, L.R.,Payne, J.A.,Shewchuk, L.M.,Willard, D.H.,Wright, L.L. (deposition date: 2005-01-17, release date: 2005-07-19, Last modification date: 2023-08-23)
Primary citation	Barrett, D.G.,Deaton, D.N.,Hassell, A.M.,McFadyen, R.B.,Miller, A.B.,Miller, L.R.,Payne, J.A.,Shewchuk, L.M.,Willard, D.H.,Wright, L.L. Acyclic cyanamide-based inhibitors of cathepsin K. Bioorg.Med.Chem.Lett., 15:3039-3043, 2005 Cited by PubMed: 15896958 DOI: 10.1016/j.bmcl.2005.04.032 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.6 Å)

Structure validation