1YHO
Solution structure of human dihydrofolate reductase complexed with trimethoprim and nadph, 25 structures
Summary for 1YHO
| Entry DOI | 10.2210/pdb1yho/pdb |
| Related | 1KMS 1KMV 1LUD |
| NMR Information | BMRB: 5981 |
| Descriptor | Dihydrofolate reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 2,4-DIAMINO-5-(3,4,5-TRIMETHOXY-BENZYL)-PYRIMIDIN-1-IUM (3 entities in total) |
| Functional Keywords | dhfr, inhibitor-enzyme complex, oxidoreductase |
| Biological source | Homo sapiens (human) |
| Total number of polymer chains | 1 |
| Total formula weight | 22386.27 |
| Authors | Polshakov, V.I.,Birdsall, B. (deposition date: 2005-01-10, release date: 2005-11-22, Last modification date: 2022-03-02) |
| Primary citation | Kovalevskaya, N.V.,Smurnyy, Y.D.,Polshakov, V.I.,Birdsall, B.,Bradbury, A.F.,Frenkiel, T.,Feeney, J. Solution structure of human dihydrofolate reductase in its complex with trimethoprim and NADPH. J.Biomol.Nmr, 33:69-72, 2005 Cited by PubMed: 16222560DOI: 10.1007/s10858-005-1475-z PDB entries with the same primary citation |
| Experimental method | SOLUTION NMR |
Structure validation
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