1YHM

Structure of the complex of Trypanosoma cruzi farnesyl disphosphate synthase with alendronate, Isopentenyl diphosphate and mg+2

1YHM の概要

• エントリーDOI: 10.2210/pdb1yhm/pdb
• 関連するPDBエントリー: 1YHK 1YHL
• 分子名称: farnesyl pyrophosphate synthase, MAGNESIUM ION, SULFATE ION, ... (6 entities in total)
• 機能のキーワード: farnesyl diphosphate synthase, alendronate, isopentenyl diphosphate, mevalonate patway, geranyl transferase, dimethylallyl transferase, fpps, transferase
• 由来する生物種: Trypanosoma cruzi
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 127766.64

構造登録者

Gabelli, S.B.,McLellan, J.S.,Montalvetti, A.,Oldfield, E.,Docampo, R.,Amzel, L.M. (登録日: 2005-01-09, 公開日: 2005-12-20, 最終更新日: 2023-11-15)

• 主引用文献: Gabelli, S.B.,McLellan, J.S.,Montalvetti, A.,Oldfield, E.,Docampo, R.,Amzel, L.M.; Structure and mechanism of the farnesyl diphosphate synthase from Trypanosoma cruzi: Implications for drug design.; Proteins, 62:80-88, 2005; PubMed: 16288456; DOI: 10.1002/prot.20754

実験手法

X-RAY DIFFRACTION (2.5 Å)