1YHM
Structure of the complex of Trypanosoma cruzi farnesyl disphosphate synthase with alendronate, Isopentenyl diphosphate and mg+2
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004659 | molecular_function | prenyltransferase activity |
| A | 0008299 | biological_process | isoprenoid biosynthetic process |
| A | 0016765 | molecular_function | transferase activity, transferring alkyl or aryl (other than methyl) groups |
| B | 0004659 | molecular_function | prenyltransferase activity |
| B | 0008299 | biological_process | isoprenoid biosynthetic process |
| B | 0016765 | molecular_function | transferase activity, transferring alkyl or aryl (other than methyl) groups |
| C | 0004659 | molecular_function | prenyltransferase activity |
| C | 0008299 | biological_process | isoprenoid biosynthetic process |
| C | 0016765 | molecular_function | transferase activity, transferring alkyl or aryl (other than methyl) groups |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MG A 401 |
| Chain | Residue |
| A | ASP250 |
| A | AHD901 |
| A | HOH905 |
| A | HOH906 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG A 402 |
| Chain | Residue |
| A | HOH903 |
| A | ASP98 |
| A | ASP102 |
| A | MG403 |
| A | AHD901 |
| A | HOH902 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE MG A 403 |
| Chain | Residue |
| A | ASP98 |
| A | ASP102 |
| A | ASP170 |
| A | MG402 |
| A | AHD901 |
| A | HOH904 |
| A | HOH907 |
| site_id | AC4 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 A 370 |
| Chain | Residue |
| A | HIS141 |
| B | LYS158 |
| site_id | AC5 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 B 1370 |
| Chain | Residue |
| B | GLN21 |
| B | HIS141 |
| site_id | AC6 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 C 2370 |
| Chain | Residue |
| C | GLN21 |
| C | HIS141 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG B 1401 |
| Chain | Residue |
| B | ASP250 |
| B | AHD1901 |
| B | HOH1906 |
| B | HOH1907 |
| B | HOH1909 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG B 1402 |
| Chain | Residue |
| B | ASP98 |
| B | ASP102 |
| B | MG1403 |
| B | AHD1901 |
| B | HOH1903 |
| B | HOH1904 |
| site_id | AC9 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE MG B 1403 |
| Chain | Residue |
| B | ASP98 |
| B | ASP102 |
| B | ASP170 |
| B | MG1402 |
| B | AHD1901 |
| B | HOH1902 |
| B | HOH1905 |
| B | HOH1908 |
| site_id | BC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG C 2401 |
| Chain | Residue |
| C | ASP250 |
| C | AHD2901 |
| C | HOH2906 |
| C | HOH2907 |
| C | HOH2909 |
| site_id | BC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG C 2402 |
| Chain | Residue |
| C | ASP98 |
| C | ASP102 |
| C | MG2403 |
| C | AHD2901 |
| C | HOH2903 |
| C | HOH2904 |
| site_id | BC3 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE MG C 2403 |
| Chain | Residue |
| C | ASP98 |
| C | ASP102 |
| C | MG2402 |
| C | AHD2901 |
| C | HOH2902 |
| C | HOH2905 |
| C | HOH2908 |
| site_id | BC4 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE AHD A 901 |
| Chain | Residue |
| A | ASP98 |
| A | ASP102 |
| A | ARG107 |
| A | LYS207 |
| A | TYR211 |
| A | GLN247 |
| A | ASP250 |
| A | LYS264 |
| A | MG401 |
| A | MG402 |
| A | MG403 |
| A | IPE900 |
| A | HOH902 |
| A | HOH903 |
| A | HOH904 |
| A | HOH905 |
| A | HOH906 |
| site_id | BC5 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE IPE A 900 |
| Chain | Residue |
| A | GLY47 |
| A | LYS48 |
| A | ARG51 |
| A | GLN91 |
| A | ARG108 |
| A | THR208 |
| A | TYR211 |
| A | PHE246 |
| A | LYS362 |
| A | AHD901 |
| site_id | BC6 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE AHD B 1901 |
| Chain | Residue |
| B | HOH1902 |
| B | HOH1904 |
| B | HOH1905 |
| B | HOH1906 |
| B | HOH1907 |
| B | HOH1909 |
| B | ASP98 |
| B | ASP102 |
| B | ARG107 |
| B | LYS207 |
| B | TYR211 |
| B | GLN247 |
| B | ASP250 |
| B | LYS264 |
| B | MG1401 |
| B | MG1402 |
| B | MG1403 |
| B | IPE1900 |
| site_id | BC7 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE IPE B 1900 |
| Chain | Residue |
| B | GLY47 |
| B | LYS48 |
| B | ARG51 |
| B | GLN91 |
| B | ARG108 |
| B | THR208 |
| B | TYR211 |
| B | PHE246 |
| B | ASP250 |
| B | LYS362 |
| B | AHD1901 |
| B | HOH1924 |
| B | HOH1932 |
| B | HOH1943 |
| site_id | BC8 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE AHD C 2901 |
| Chain | Residue |
| C | ASP98 |
| C | ASP102 |
| C | ARG107 |
| C | GLN167 |
| C | LYS207 |
| C | GLN247 |
| C | ASP250 |
| C | LYS264 |
| C | MG2401 |
| C | MG2402 |
| C | MG2403 |
| C | IPE2900 |
| C | HOH2902 |
| C | HOH2904 |
| C | HOH2905 |
| C | HOH2906 |
| C | HOH2907 |
| C | HOH2909 |
| site_id | BC9 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE IPE C 2900 |
| Chain | Residue |
| C | GLY47 |
| C | LYS48 |
| C | ARG51 |
| C | GLN91 |
| C | ARG108 |
| C | THR208 |
| C | PHE246 |
| C | GLN247 |
| C | ASP250 |
| C | LYS362 |
| C | AHD2901 |
Functional Information from PROSITE/UniProt
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1fps |
| Chain | Residue | Details |
| A | ARG107 | |
| A | PHE246 |
| site_id | CSA2 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1fps |
| Chain | Residue | Details |
| B | ARG107 | |
| B | PHE246 |
| site_id | CSA3 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1fps |
| Chain | Residue | Details |
| C | ARG107 | |
| C | PHE246 |
