1YHD
The solution structure of YGGX from Escherichia Coli
Summary for 1YHD
| Entry DOI | 10.2210/pdb1yhd/pdb |
| Descriptor | UPF0269 protein yggX (1 entity in total) |
| Functional Keywords | helix bundle, unknown function |
| Biological source | Escherichia coli |
| Total number of polymer chains | 1 |
| Total formula weight | 12096.74 |
| Authors | Osborne, M.J.,Siddiqui, N.,Landgraf, D.,Pomposiello, P.J.,Gehring, K. (deposition date: 2005-01-07, release date: 2005-01-18, Last modification date: 2024-05-22) |
| Primary citation | Osborne, M.J.,Siddiqui, N.,Landgraf, D.,Pomposiello, P.J.,Gehring, K. The solution structure of the oxidative stress-related protein YggX from Escherichia coli. Protein Sci., 14:1673-1678, 2005 Cited by PubMed Abstract: YggX is a highly conserved protein found only in eubacteria and is proposed to be involved in the bacterial response to oxidative stress. Here we report the solution structure of YggX from Escherichia coli determined by nuclear magnetic resonance spectroscopy. The structure of YggX displays a fold consisting of two N-terminal antiparallel beta-sheets and three alpha-helices, which shares significant structural similarity to the crystal structure of a hypothetical protein PA5148 from Pseudomonas aeruginosa. Previous studies propose YggX as an iron binding protein that is involved in cellular iron trafficking. Our data indicate that the protein alone does not bind iron in vitro, suggesting other cofactors or different conditions may be necessary for metal binding. PubMed: 15883188DOI: 10.1110/ps.051358105 PDB entries with the same primary citation |
| Experimental method | SOLUTION NMR |
Structure validation
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