1YGC

Short Factor VIIa with a small molecule inhibitor

Summary for 1YGC

• Entry DOI: 10.2210/pdb1ygc/pdb
• Related: 1DAN 1KLI 1KLJ 1jbu
• Descriptor: Coagulation factor VII, CALCIUM ION, SULFATE ION, ... (6 entities in total)
• Functional Keywords: inverted oxy-anion hole, hydrolase
• Biological source: Homo sapiens (human); More
• Cellular location: Secreted: P08709 P08709
• Total number of polymer chains: 2
• Total formula weight: 36273.19

Authors

Olivero, A.G.,Eigenbrot, C.,Goldsmith, R.,Robarge, K.,Artis, D.R.,Flygare, J.,Rawson, T.,Refino, C.,Bunting, S.,Kirchhofer, D. (deposition date: 2005-01-04, release date: 2005-01-18, Last modification date: 2011-07-13)

• Primary citation: Olivero, A.G.,Eigenbrot, C.,Goldsmith, R.,Robarge, K.,Artis, D.R.,Flygare, J.,Rawson, T.,Sutherlin, D.P.,Kadkhodayan, S.,Beresini, M.,Elliott, L.O.,DeGuzman, G.G.,Banner, D.W.,Ultsch, M.,Marzec, U.,Hanson, S.R.,Refino, C.,Bunting, S.,Kirchhofer, D.; A selective, slow binding inhibitor of factor VIIa binds to a nonstandard active site conformation and attenuates thrombus formation in vivo.; J.Biol.Chem., 280:9160-9169, 2005; PubMed: 15632123; DOI: 10.1074/jbc.M409068200

Experimental method

X-RAY DIFFRACTION (2 Å)