1YCP

THE CRYSTAL STRUCTURE OF FIBRINOGEN-AA PEPTIDE 1-23 (F8Y) BOUND TO BOVINE THROMBIN EXPLAINS WHY THE MUTATION OF PHE-8 TO TYROSINE STRONGLY INHIBITS NORMAL CLEAVAGE AT ARGININE-16

1YCP の概要

• エントリーDOI: 10.2210/pdb1ycp/pdb
• 分子名称: EPSILON THROMBIN, ALPHA THROMBIN, FIBRINOPEPTIDE A-ALPHA, ... (6 entities in total)
• 機能のキーワード: fibrinopeptide-a, complex (serine protease-peptide), thrombin, hydrolase-hydrolase substrate complex, hydrolase/hydrolase substrate
• 由来する生物種: Bos taurus (cattle); 詳細
• 細胞内の位置: Secreted, extracellular space: P00735 P00735 P00735 P00735; Secreted: P02671
• タンパク質・核酸の鎖数: 7
• 化学式量合計: 75732.31

構造登録者

Malkowski, M.G.,Edwards, B.F.P. (登録日: 1997-05-01, 公開日: 1998-05-06, 最終更新日: 2021-11-03)

• 主引用文献: Malkowski, M.G.,Martin, P.D.,Lord, S.T.,Edwards, B.F.; Crystal structure of fibrinogen-Aalpha peptide 1-23 (F8Y) bound to bovine thrombin explains why the mutation of Phe-8 to tyrosine strongly inhibits normal cleavage at Arg-16.; Biochem.J., 326:815-822, 1997; PubMed: 9307032

実験手法

X-RAY DIFFRACTION (2.5 Å)