1YA4

Crystal Structure of Human Liver Carboxylesterase 1 in complex with tamoxifen

Summary for 1YA4

Entry DOI	10.2210/pdb1ya4/pdb
Related	1MX1 1MX5 1MX9 1ya8 1yah 1yaj
Descriptor	CES1 protein, 2-acetamido-2-deoxy-beta-D-glucopyranose, N-acetyl-alpha-neuraminic acid, ... (6 entities in total)
Functional Keywords	hydrolase domain, tamoxifen complex, hydrolase
Biological source	Homo sapiens (human)
Total number of polymer chains	3
Total formula weight	180413.58
Authors	Fleming, C.D.,Bencharit, S.,Edwards, C.C.,Hyatt, J.L.,Morton, C.L.,Howard-Williams, E.L.,Potter, P.M.,Redinbo, M.R. (deposition date: 2004-12-17, release date: 2005-08-02, Last modification date: 2023-08-23)
Primary citation	Fleming, C.D.,Bencharit, S.,Edwards, C.C.,Hyatt, J.L.,Tsurkan, L.,Bai, F.,Fraga, C.,Morton, C.L.,Howard-Williams, E.L.,Potter, P.M.,Redinbo, M.R. Structural insights into drug processing by human carboxylesterase 1: tamoxifen, mevastatin, and inhibition by benzil. J.Mol.Biol., 352:165-177, 2005 Cited by PubMed: 16081098 DOI: 10.1016/j.jmb.2005.07.016 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.2 Å)

Structure validation