1Y91
Crystal structure of human CDK2 complexed with a pyrazolo[1,5-a]pyrimidine inhibitor
Summary for 1Y91
Entry DOI | 10.2210/pdb1y91/pdb |
Related | 1Y8Y |
Descriptor | Cell division protein kinase 2, 4-[5-(TRANS-4-AMINOCYCLOHEXYLAMINO)-3-ISOPROPYLPYRAZOLO[1,5-A]PYRIMIDIN-7-YLAMINO]-N,N-DIMETHYLBENZENESULFONAMIDE (3 entities in total) |
Functional Keywords | serine/threonine protein kinase, cdk2, atp-binding, cell cycle, mitosis, phosphorylation, pyrazolopyrimidine inhibitor, transferase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 34448.11 |
Authors | Williamson, D.S.,Parratt, M.J.,Torrance, C.J.,Bower, J.F.,Moore, J.D.,Richardson, C.M.,Dokurno, P.,Cansfield, A.D.,Francis, G.L.,Hebdon, R.J.,Howes, R.,Jackson, P.S.,Lockie, A.M.,Murray, J.B.,Nunns, C.L.,Powles, J.,Robertson, A.,Surgenor, A.E. (deposition date: 2004-12-14, release date: 2005-02-08, Last modification date: 2023-08-23) |
Primary citation | Williamson, D.S.,Parratt, M.J.,Bower, J.F.,Moore, J.D.,Richardson, C.M.,Dokurno, P.,Cansfield, A.D.,Francis, G.L.,Hebdon, R.J.,Howes, R.,Jackson, P.S.,Lockie, A.M.,Murray, J.B.,Nunns, C.L.,Powles, J.,Robertson, A.,Surgenor, A.E.,Torrance, C.J. Structure-guided design of pyrazolo[1,5-a]pyrimidines as inhibitors of human cyclin-dependent kinase 2. Bioorg.Med.Chem.Lett., 15:863-867, 2005 Cited by PubMed: 15686876DOI: 10.1016/j.bmcl.2004.12.073 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.15 Å) |
Structure validation
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