1Y8J

Crystal Structure of human NEP complexed with an imidazo[4,5-c]pyridine inhibitor

Summary for 1Y8J

Entry DOI	10.2210/pdb1y8j/pdb
Related	1DMT 1R1H 1R1I 1R1J
Descriptor	Neprilysin, 2-acetamido-2-deoxy-beta-D-glucopyranose, ZINC ION, ... (6 entities in total)
Functional Keywords	lt1_6, hydrolase
Biological source	Homo sapiens (human)
Cellular location	Cell membrane; Single-pass type II membrane protein: P08473
Total number of polymer chains	1
Total formula weight	80583.96
Authors	Sahli, S.,Frank, B.,Schweizer, W.B.,Diederich, F.,Blum-Kaelin, D.,Aebi, J.D.,Bohm, H.J.,Oefner, C.,Dale, G.E. (deposition date: 2004-12-13, release date: 2005-06-07, Last modification date: 2023-08-23)
Primary citation	Sahli, S.,Frank, B.,Schweizer, W.B.,Diederich, F.,Blum-Kaelin, D.,Aebi, J.D.,Bohm, H.J.,Oefner, C.,Dale, G.E. Second-Generation Inhibitors for the Metalloprotease Neprilysin Based on Bicyclic Heteroaromatic Scaffolds: Synthesis, Biological Activity, and X-ray Crystal Structure Analysis HELV.CHIM.ACTA, 88:731-750, 2005 Cited by DOI: 10.1002/hlca.200590051 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.25 Å)

Structure validation