1Y6E

Orthorhombic glutathione S-transferase of Schistosoma japonicum

Summary for 1Y6E

Entry DOI	10.2210/pdb1y6e/pdb
Descriptor	glutathione S-transferase (2 entities in total)
Functional Keywords	dimer, transferase
Biological source	Schistosoma japonicum
Total number of polymer chains	2
Total formula weight	52144.58
Authors	Rufer, A.C.,Thiebach, L.,Baer, K.,Klein, H.W.,Hennig, M. (deposition date: 2004-12-06, release date: 2005-03-08, Last modification date: 2024-03-13)
Primary citation	Rufer, A.C.,Thiebach, L.,Baer, K.,Klein, H.W.,Hennig, M. X-ray structure of glutathione S-transferase from Schistosoma japonicum in a new crystal form reveals flexibility of the substrate-binding site Acta Crystallogr.,Sect.F, 61:263-265, 2005 Cited by PubMed Abstract: The crystal structure of the 26 kDa glutathione S-transferase from Schistosoma japonicum (SjGST) was determined at 3 A resolution in the new space group P2(1)2(1)2(1). The structure of orthorhombic SjGST reveals unique features of the ligand-binding site and dimer interface when compared with previously reported structures. SjGST is recognized as the major detoxification enzyme of S. japonicum, a pathogenic helminth causing schistosomiasis. As resistance against the established inhibitor of SjGST, praziquantel, has been reported these results might prove to be valuable for the development of novel drugs. PubMed: 16511012 DOI: 10.1107/S1744309105004823 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3 Å)

Structure validation