1Y0H

Structure of Rv0793 from Mycobacterium tuberculosis

1Y0H の概要

• エントリーDOI: 10.2210/pdb1y0h/pdb
• 分子名称: hypothetical protein Rv0793, ACETATE ION (3 entities in total)
• 機能のキーワード: ferredoxin-like fold, alpha+beta sandwich with antiparallel beta-sheet, structural genomics, psi, protein structure initiative, tb structural genomics consortium, tbsgc, unknown function
• 由来する生物種: Mycobacterium tuberculosis
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 22702.67

構造登録者

Lemieux, M.J.,Ference, C.,Cherney, M.M.,Wang, M.,Garen, C.,James, M.N.,TB Structural Genomics Consortium (TBSGC) (登録日: 2004-11-15, 公開日: 2004-12-28, 最終更新日: 2024-02-14)

主引用文献

Lemieux, M.J.,Ference, C.,Cherney, M.M.,Wang, M.,Garen, C.,James, M.N.
The crystal structure of Rv0793, a hypothetical monooxygenase from M. tuberculosis
J.STRUCT.FUNCT.GENOM., 6:245-257, 2005

PubMed Abstract: Mycobacterium tuberculosis infects millions worldwide. The Structural Genomics Consortium for M. tuberculosis has targeted all genes from this bacterium in hopes of discovering and developing new therapeutic agents. Open reading frame Rv0793 from M. tuberculosis was annotated with an unknown function. The 3-dimensional structure of Rv0793 has been solved to 1.6 A resolution. Its structure is very similar to that of Streptomyces coelicolor ActVA-Orf6, a monooxygenase that participates in tailoring of polyketide antibiotics in the absence of a cofactor. It is also similar to the recently solved structure of YgiN, a quinol monooxygenase from Escherichia coli. In addition, the structure of Rv0793 is similar to several structures of other proteins with unknown function. These latter structures have been determined recently as a result of structural genomic projects for various bacterial species. In M. tuberculosis, Rv0793 and its homologs may represent a class of monooygenases acting as reactive oxygen species scavengers that are essential for evading host defenses. Since the most prevalent mode of attack by the host defense on M. tuberculosis is by reactive oxygen species and reactive nitrogen species, Rv0793 may provide a novel target to combat infection by M. tuberculosis.

PubMed: 16496224
DOI: 10.1007/s10969-005-9004-6

実験手法

X-RAY DIFFRACTION (1.6 Å)