1XUU

Crystal structure of sialic acid synthase (NeuB) in complex with Mn2+ and Malate from Neisseria meningitidis

Summary for 1XUU

Entry DOI	10.2210/pdb1xuu/pdb
Related	1XUZ
Descriptor	polysialic acid capsule biosynthesis protein SiaC, MANGANESE (II) ION, D-MALATE, ... (4 entities in total)
Functional Keywords	tim barrel, antifreeze-like domain, domain-swapped dimer, biosynthetic protein
Biological source	Neisseria meningitidis
Total number of polymer chains	1
Total formula weight	38584.76
Authors	Gunawan, J.,Simard, D.,Gilbert, M.,Lovering, A.L.,Wakarchuk, W.W.,Tanner, M.E.,Strynadka, N.C. (deposition date: 2004-10-26, release date: 2004-11-02, Last modification date: 2024-02-14)
Primary citation	Gunawan, J.,Simard, D.,Gilbert, M.,Lovering, A.L.,Wakarchuk, W.W.,Tanner, M.E.,Strynadka, N.C. Structural and mechanistic analysis of sialic acid synthase NeuB from Neisseria meningitidis in complex with Mn2+, phosphoenolpyruvate, and N-acetylmannosaminitol. J.Biol.Chem., 280:3555-3563, 2005 Cited by PubMed: 15516336 DOI: 10.1074/jbc.M411942200 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation