1XU7

Crystal Structure of the Interface Open Conformation of Tetrameric 11b-HSD1

Summary for 1XU7

Entry DOI	10.2210/pdb1xu7/pdb
Related	1XU9
Descriptor	Corticosteroid 11-beta-dehydrogenase, isozyme 1, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE, ... (4 entities in total)
Functional Keywords	11b-hsd1, sdr, dehydrogenase, hydroxysteroid, oxidoreductase
Biological source	Homo sapiens (human)
Cellular location	Endoplasmic reticulum membrane; Single-pass type II membrane protein: P28845
Total number of polymer chains	4
Total formula weight	134018.45
Authors	Hosfield, D.J.,Wu, Y.,Skene, R.J.,Hilger, M.,Jennings, A.,Snell, G.P.,Aertgeerts, K. (deposition date: 2004-10-25, release date: 2004-11-02, Last modification date: 2024-02-14)
Primary citation	Hosfield, D.J.,Wu, Y.,Skene, R.J.,Hilger, M.,Jennings, A.,Snell, G.P.,Aertgeerts, K. Conformational Flexibility in Crystal Structures of Human 11beta-hydroxysteroid dehydrogenase type I provide insights into glucocorticoid interconversion and enzyme regulation. J.Biol.Chem., 280:4639-4648, 2005 Cited by PubMed: 15513927 DOI: 10.1074/jbc.M411104200 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation