1XU2

The crystal structure of APRIL bound to BCMA

1XU2 の概要

• エントリーDOI: 10.2210/pdb1xu2/pdb
• 関連するPDBエントリー: 1U5X 1U5Y 1U5Z 1XU1 1XUT
• 分子名称: Tumor necrosis factor ligand superfamily member 13, Tumor necrosis factor receptor superfamily member 17, NICKEL (II) ION, ... (4 entities in total)
• 機能のキーワード: tnfsf, cytokine, crd, receptor, jelly-roll, cysteine-rich, hormone-growth factor receptor complex, hormone/growth factor receptor
• 由来する生物種: Mus musculus (house mouse); 詳細
• 細胞内の位置: Secreted (By similarity): Q9D777; Cell membrane; Single-pass type III membrane protein: Q02223
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 62082.66

構造登録者

Hymowitz, S.G.,Patel, D.R.,Wallweber, H.J.A.,Runyon, S.,Yan, M.,Yin, J.,Shriver, S.K.,Gordon, N.C.,Pan, B.,Skelton, N.J.,Kelley, R.F.,Starovasnik, M.A. (登録日: 2004-10-25, 公開日: 2004-11-09, 最終更新日: 2023-08-23)

• 主引用文献: Hymowitz, S.G.,Patel, D.R.,Wallweber, H.J.A.,Runyon, S.,Yan, M.,Yin, J.,Shriver, S.K.,Gordon, N.C.,Pan, B.,Skelton, N.J.,Kelley, R.F.,Starovasnik, M.A.; Structures of APRIL-receptor complexes: Like BCMA, TACI employs only a single cysteine-rich domain for high-affinity ligand binding; J.Biol.Chem., 280:7218-7227, 2005; PubMed: 15542592; DOI: 10.1074/jbc.M411714200

実験手法

X-RAY DIFFRACTION (2.35 Å)